Association of Tumor Pathological Response with the Use of Metformin During Neoadjuvant Chemoradiotherapy in Rectal and Esophageal/Gastroesophageal Cancer Patients: a Systematic Review and Meta-analysis.

Kyoko SakamotoKoji OkabayashiShimpei MatsuiRyo SeishimaKohei ShigetaYuko Kitagawa

Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2022)

The results suggest that metformin is associated with pCR rate when used in combination with NACRT. The association of metformin and pCR rate in combination with fluoropyrimidine anticancer drugs was observed mostly for adenocarcinoma patients.

Keyphrases

rectal cancer
locally advanced
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
lymph node
prognostic factors
patient reported outcomes