NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.

Yoichi KakutaYosuke KawaiDaisuke OkamotoTetsuya TakagawaKentaro IkeyaHirotake SakurabaAtsushi NishidaShoko NakagawaMiki MiuraTakahiko ToyonagaKei OnoderaMasaru ShinozakiYoh IshiguroShinta MizunoMasahiro TakaharaShunichi YanaiRyota HokariTomoo NakagawaHiroshi ArakiSatoshi MotoyaTakeo NaitoRintaro MoroiHisashi ShigaKatsuya EndoTaku KobayashiMakoto NaganumaSakiko HiraokaTakayuki MatsumotoShiro NakamuraHiroshi NakaseTadakazu HisamatsuMakoto SasakiHiroyuki HanaiAkira AndohMasao NagasakiYoshitaka KinouchiTooru ShimosegawaAtsushi MasamuneYasuo Suzukinull null

Published in: Journal of gastroenterology (2018)

Genotyping of NUDT15 codon 139 was sufficient to predict acute severe leukopenia and alopecia in Japanese patients with IBD.

Keyphrases

drug induced
patients with inflammatory bowel disease
early onset
liver failure
diabetic rats
high glucose
respiratory failure
high throughput
oxidative stress
hepatitis b virus
dna methylation
ulcerative colitis