Erythropoietin promotes the differentiation of fetal neural stem cells into glial cells via the erythropoietin receptor-β common receptor/Syne-1/H3K9me3 pathway.

Zhen-Hong YangSi-Jia ZhangHai-Ping ZhaoFang-Fang LiZhen TaoYu-Min LuoRong-Liang Wang

Published in: CNS neuroscience & therapeutics (2022)

EPO treatment immediately after OGD/R could not facilitate fetal NSCs/NPs neurogenesis but promoted the formation of the EPOR/βCR heterodimer on fetal NSCs/NPs, which mediates its function in glial differentiation.

Keyphrases

neural stem cells
induced apoptosis
neuropathic pain
recombinant human
cell cycle arrest
cell death
signaling pathway
endoplasmic reticulum stress
combination therapy
cerebral ischemia