Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition.

Valeria Di GiovanniCeline BourdonDominic X WangSwapna SeshadriEdward SengaChristian J VerslootWieger VoskuijlRichard D SembaIndi TrehanRuin MoaddelM Isabel OrdizLing ZhangJohn ParkinsonMark J ManaryRobert Hj Bandsma

Published in: The Journal of nutrition (2016)

Children with kwashiorkor were metabolically distinct from those with marasmus, and were more prone to severe metabolic disruptions. Children with SAM showed metabolic profiles that were profoundly different from stunted and nonstunted controls, even after clinical stabilization. Therefore, metabolic recovery in children with SAM likely extends beyond discharge, which may explain the poor long-term outcomes in these children. This trial was registered at isrctn.org as ISRCTN13916953.

Keyphrases

young adults
clinical trial
study protocol
early onset
open label
phase ii