Micro-CT and high-field MRI for studying very early post-mortem human fetal anatomy at 8 weeks of gestation.
Audrey LamourouxMaïda CardosoCélia BotteroMathieu GalloMartha DuraesJennifer SalernoMartin M BertrandValérie RigauFlorent FuchsEve MoustyDavid GenevieveGérard SubsolChristophe Goze-BacGuillaume CaptierPublished in: Prenatal diagnosis (2023)
PM non-destructive whole-body multimodal micro-imaging: dice micro-CT and HF-MRI allows for PM human fetal anatomy study as early as 8 WG. It paves the way to virtual autopsy in the very early first trimester. Obtaining a precision phenotype, even regarding miscarriage products, allows a reverse phenotyping to select variants of interest in genome-wide analysis, offering potential genetic counseling for bereaved parents.
Keyphrases
- contrast enhanced
- endothelial cells
- magnetic resonance imaging
- computed tomography
- particulate matter
- air pollution
- genome wide analysis
- image quality
- induced pluripotent stem cells
- heavy metals
- copy number
- dual energy
- high resolution
- preterm infants
- diffusion weighted imaging
- gestational age
- positron emission tomography
- genome wide
- magnetic resonance
- high throughput
- dna methylation
- gene expression
- preterm birth
- chronic pain
- human health
- acute heart failure