Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention.
Floriana Jessica Di PaolaChiara AlquatiGabriele ContiGiulia CalafatoSilvia TurroniFederica D'AmicoClaudio CeccarelliFrancesco ButtittaAlice BernardiDajana CuicchiGilberto PoggioliDaniela TurchettiSimona FerrariRenato CannizzaroStefano RealdonPatrizia BrigidiLuigi RicciardielloPublished in: Journal of translational medicine (2024)
Our study reveals an interplay between Wnt/β-catenin and PI3K/mTOR, whose derangement correlates with specific microbiota signatures in FAP and CRC patients, and identifies new potential biomarkers and targets to improve CRC prevention, early adenoma detection and treatment.
Keyphrases
- cell proliferation
- end stage renal disease
- stem cells
- ejection fraction
- genome wide
- newly diagnosed
- chronic kidney disease
- prognostic factors
- epithelial mesenchymal transition
- peritoneal dialysis
- electronic health record
- dna methylation
- patient reported outcomes
- big data
- signaling pathway
- machine learning
- combination therapy
- artificial intelligence