Increased nuchal translucency with normal karyotype and genomic microarray analysis: A multicenter observational study.

Elisa SpataroAdalgisa CordiscoCarlo LuchiGilda Rosaria FilardiGiulia MasiniLucia Pasquini

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2022)

In fetuses with an NT of 3.5 mm or more and both normal karyotype and array-CGH, the rate of morbidity-related outcome depends on NT size. A normal RASopathy testing and mid-trimester ultrasound are reassuring but the residual risk of morbidity-related outcome is increased compared with the general population, particularly if NT is greater than 6 mm.

Keyphrases

magnetic resonance imaging
high throughput
gene expression
preterm birth
pregnant women