Login / Signup

Photoredox-Catalyzed Intermolecular Hydroalkylative Dearomatization of Electron-Deficient Indole Derivatives.

Xu-Lun HuangYuan-Zheng ChengXiao ZhangShu-Li You
Published in: Organic letters (2020)
Dearomatization of indole derivatives offers a straightforward approach to access diverse indolines. To date, the corresponding dearomative transformations involving electron-deficient indoles are limited. Herein, we report a one-electron strategy for dearomatization of electron-deficient indoles via a photoredox-catalyzed hydroalkylation employing commercially available glycine derivatives as the hydrofunctionalization reagents. Followed by DBU-mediated lactamization, structurally appealing lactam-fused indolines are obtained in good to excellent yields with exclusive selectivity.
Keyphrases
  • solar cells
  • room temperature
  • electron microscopy
  • visible light
  • wild type
  • quantum dots