Neuroprotective effects of ex vivo-expanded regulatory T cells on trimethyltin-induced neurodegeneration in mice.
Seon-Young ParkHyeJin YangMinsook YeXiao LiuInsop ShimYoung-Tae ChangHyunsu BaePublished in: Journal of neuroinflammation (2022)
These data suggest that adoptive transfer of Tregs ameliorates disease progression in TMT-induced neurodegeneration by promoting neurogenesis and modulating microglial activation and polarization.
Keyphrases
- regulatory t cells
- high glucose
- diabetic rats
- dendritic cells
- drug induced
- cell therapy
- signaling pathway
- endothelial cells
- oxidative stress
- metabolic syndrome
- big data
- mouse model
- spinal cord
- immune response
- high fat diet induced
- adipose tissue
- lps induced
- skeletal muscle
- subarachnoid hemorrhage
- artificial intelligence
- stress induced
- cerebral ischemia