Calcineurin Controls Hypothalamic NMDA Receptor Activity and Sympathetic Outflow.
Jing-Jing ZhouJian-Ying ShaoShao-Rui ChenHui-Lin Pan 潘惠麟Published in: Circulation research (2022)
Our findings reveal that normal calcineurin activity in the PVN constitutively restricts sympathetic vasomotor tone via suppressing NMDA receptor activity, which may be targeted for treating calcineurin inhibitor-induced hypertension.