Evaluation of a 27-gene inherited cancer panel across 630 consecutive patients referred for testing in a clinical diagnostic laboratory.

Sabrina A GardnerKatelyn S WeymouthWei S KellyEkaterina BogdanovaWenjie ChenDaniel LupuJoshua SuhlQiandong ZengUte GeigenmüllerDebbie BolesPatricia M OkamotoGeraldine McDowellMelissa A HaydenNarasimhan Nagan

Published in: Hereditary cancer in clinical practice (2018)

These results provide the actual percentage of family or personal history of cancer that can be attributed to pathogenic or likely pathogenic variants in one or more of the genes on our panel and corroborate the utility of multi-gene panels over sequential testing to identify individuals with an inherited predisposition to cancer.

Keyphrases

papillary thyroid
squamous cell
copy number
genome wide
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
young adults
peritoneal dialysis