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Association of Cholinergic Muscarinic M4 Receptor Gene Polymorphism with Schizophrenia.

Ivan V PozhidaevAnastasiia S BoikoAnton J M LoonenDiana Z PaderinaOlga Yu FedorenkoGennadiy TeninElena G KornetovaArkadiy V SemkeNikolay A BokhanBob WilffertSvetlana A Ivanova
Published in: The application of clinical genetics (2020)
Our study found the presence of the minor allele (T) of rs2067482 variant being associated with schizophrenia. We argue that the association of rs2067482 with schizophrenia may be via its regulatory effect on some other gene with protein kinase C and casein Kknase substrate in neurons 3 (PACSIN3) as a possible candidate. Neither rs2067482 nor rs72910092 is associated with tardive dyskinesia.
Keyphrases
  • bipolar disorder
  • protein kinase
  • transcription factor
  • genome wide
  • gene expression
  • copy number
  • dna methylation
  • genome wide analysis