Pathological downstaging as a novel endpoint for the development of neoadjuvant chemotherapy for upper tract urothelial carcinoma.
Alberto MartiniJorge DazaElona PoltiyelovaZeynep GulJohn R HeardBart S FerketNikhil WaingankarMatthew D GalskyJohn P SfakianosPublished in: BJU international (2019)
The study showed that pDS after NAC for UTUC was more informative than pCR when predicting OS. These findings, although requiring prospective validation, can aid in the design of clinical trials seeking to refine the use of chemotherapy and other systemic therapies in this setting.