A case series of osseous metastases in patients with glioblastoma.

Lauren Michelle WebbMason J WebbJian L CampianSamantha J CaronMichael W RuffJoon H UhmUgur T Sener

Published in: Medicine (2024)

In our cohort, most patients were male and young at the time of GBM diagnosis. All patients had IDH-wildtype, MGMT promoter unmethylated GBM, and most had alterations in TP53, which may be important for osseous metastasis. Most patients received bevacizumab, which has been associated with earlier metastasis. Osseous metastases of GBM occur and portend a dismal prognosis in an already aggressive malignancy.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
gene expression
transcription factor
patient reported outcomes
low grade
dna methylation
middle aged