Impact of the First Twenty-Four-Hour Area Under the Concentration-Time Curve/Minimum Inhibitory Concentration of Vancomycin on Treatment Outcomes in Patients With Methicillin-Resistant Staphylococcus aureus Bacteremia.
Mika HigashiTakafumi NakanoKeisuke SatoYukiomi EguchiNorihiro MoriwakiMitsuhiro KamadaTadahiro IkeuchiSusumu KaneshigeMasanobu UchiyamaToshinobu HayashiAtsushi TogawaKoichi MatsuoHidetoshi KamimuraPublished in: Journal of clinical medicine research (2024)
The first 24-h AUC/MIC had no effect on the treatment efficacy and 30-day survival rates. However, the time to clinical and bacteriological improvement was significantly prolonged in the < 300 group, indicating that the first 24-h AUC/MIC does not affect the rate of therapeutic efficacy but may affect the treatment period.