CDK7/CDK9 mediates transcriptional activation to prime paraptosis in cancer cells.

Shih-Kai ChiangWei-Chao ChangShuen-Ei ChenLing-Chu Chang

Published in: Cell & bioscience (2024)

We propose a novel regulatory paradigm in which the activation of CDK7/CDK9-Rpb1 by nuclear proteostatic stress mediates transcriptional regulation to prime cancer cell paraptosis.

Keyphrases

cell cycle
transcription factor
gene expression
cell proliferation
stress induced
heat shock