A Rare Manifestation of a Rare Disease: Mantle Cell Lymphoma Presenting With Aseptic Meningitis.
Elvira UmyarovaSreedhar R AdapaSrikanth NaramalaVijay GayamNarothama Reddy AeddulaVenu Madhav KonalaPublished in: Journal of investigative medicine high impact case reports (2020)
Mantle cell lymphoma (MCL) is a rare form of non-Hodgkin lymphoma characterized by clonal proliferation of follicular mantle zone B lymphocytes. It is caused by abnormal chromosomal translocation t(11;14) resulting in aberrant expression of cyclin D1. This leads to activation of anti-apoptotic pathways and abnormal proliferation of MCL cells. Patients can present with an indolent course or a fulminant disease with short overall survival. The disease frequently involves extranodal organs, but rarely manifests with neurological symptoms. We report a rare case of aberrant CD5-negative MCL presenting with aseptic meningitis.
Keyphrases
- rare case
- end stage renal disease
- cell death
- signaling pathway
- ejection fraction
- cell cycle arrest
- chronic kidney disease
- newly diagnosed
- case report
- prognostic factors
- cerebrospinal fluid
- brain injury
- physical activity
- hepatitis b virus
- depressive symptoms
- binding protein
- subarachnoid hemorrhage
- liver failure
- cerebral ischemia
- free survival