Innate Immunity and SARS-CoV-2 Vaccine Response in Hemodialysis Patients.

Nicolas ValentiniLorie MarchittoMaxime RaymondGuillaume GoyetteDaniel E KaufmannAndrés FinziRita S Suri Caroline Lamarche

Published in: Kidney360 (2022)

Patients receiving hemodialysis (HD) have more inflammatory monocytes and less plasmacytoid dendritic cells (DCs) compared with healthy controls.Patients on HD who have a poor antibody response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine had fewer monocyte-derived DCs and conventional DCs compared with good responders.The defects in antigen presentation might be possible therapeutic targets to increase vaccine efficacy in HD patients.

Keyphrases

dendritic cells
sars cov
end stage renal disease
respiratory syndrome coronavirus
chronic kidney disease
peritoneal dialysis
ejection fraction
newly diagnosed
immune response
regulatory t cells
coronavirus disease
oxidative stress
endothelial cells
peripheral blood
patient reported