Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study.

Alexander Kautzky Markus DoldL BartovaM SpiesG S KranzD SoueryS MontgomeryJ MendlewiczJ ZoharChiara Fabbri Alessandro SerrettiR LanzenbergerD DikeosD RujescuSiegfried Kasper

Published in: Acta psychiatrica Scandinavica (2018)

Symptom severity, suicidal risk, higher number of lifetime depressive episodes, and comorbid anxiety disorder were replicated as the most prominent risk factors for TRD. Significant predictors in TRD-III enabled robust prediction of treatment outcome in TRD-I.

Keyphrases

depressive symptoms
bipolar disorder
sleep quality
stress induced