NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness.
Mireia BachillerLorena Perez-AmillAnthony Matthew BattramSebastian Ciro CarnéAmer NajjarEls VerhoeyenManel JuanAlvaro Urbano-IspizuaBeatriz Martin-AntonioPublished in: Journal for immunotherapy of cancer (2022)
This study demonstrates a relevant immunoregulatory role of CB-NK collaborating with CAR-T cells to enhance their antitumor activity. A novel and different approach to consider in CAR-T cell immunotherapy studies is presented here with the goal to enhance the efficacy of the treatment.