A Bismuth Metal-Organic Framework as a Contrast Agent for X-ray Computed Tomography.
Lee RobisonLin ZhangRiki J DroutPeng LiChad R HaneyAnlil BrikhaHyunho NohB Layla MehdiNigel D BrowningVinayak P DravidQun CuiTimur IslamogluOmar K FarhaPublished in: ACS applied bio materials (2019)
A new bismuth metal-organic framework (MOF), bismuth-NU-901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ∼11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi 6 nodes and tetratopic 1,3,5,8-( p -benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates ∼7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ∼14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.
Keyphrases
- dual energy
- metal organic framework
- computed tomography
- contrast enhanced
- electron microscopy
- image quality
- magnetic resonance
- magnetic resonance imaging
- positron emission tomography
- high density
- oxide nanoparticles
- healthcare
- squamous cell carcinoma
- lymph node
- molecular dynamics
- visible light
- crystal structure
- high intensity
- molecular docking