A pathophysiological biomarker combination separates Lewy body from non-Lewy body neurogenic orthostatic hypotension .
Risa IsonakaPatti SullivanCourtney HolmesDavid S GoldsteinPublished in: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2024)
LB forms of nOH feature cardiac noradrenergic deficiency, olfactory dysfunction, and increased α-syn-TH colocalization in skin biopsies. Combining the data for these variables efficiently separates LB from non-LB nOH. Independently of the clinical diagnosis, this biomarker triad identifies a pathophysiologically distinct cluster of nOH patients.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- machine learning
- spinal cord injury
- prognostic factors
- left ventricular
- electronic health record
- genome wide
- heart failure
- gene expression
- dna methylation
- patient reported outcomes
- ultrasound guided
- artificial intelligence
- replacement therapy