Astrogliosis in aging and Parkinson's disease dementia: a new clinical study with 11 C-BU99008 PET.
Mohamed A MohamedZhou ZengMarta GennaroNicholas P Lao-KaimJim F M MyersValeria CalsolaroGrazia Daniela FemminellaRobin J TyackeAntonio Martin-BastidaRoger N GunnDavid J NuttPaul EdisonPaola PicciniAndreas-Antonios RoussakisPublished in: Brain communications (2022)
The role of astrogliosis in the pathology of brain aging and neurodegenerative diseases has recently drawn great attention. Imidazoline-2 binding sites represent a possible target to map the distribution of reactive astrocytes. In this study, we use 11 C-BU99008, an imidazoline-2 binding sites-specific PET radioligand, to image reactive astrocytes in vivo in healthy controls and patients with established Parkinson's disease dementia. Eighteen healthy controls (age: 45-78 years) and six patients with Parkinson's disease dementia (age: 64-77 years) had one 11 C-BU99008 PET-CT scan with arterial input function. All subjects underwent one 3 T MRI brain scan to facilitate the analysis of the PET data and to capture individual cerebral atrophy. Regional 11 C-BU99008 volumes of distribution were calculated for each subject by the two-tissue compartmental modelling. Positive correlations between 11 C-BU99008 volumes of distribution values and age were found for all tested regions across the brain within healthy controls ( P < 0.05); furthermore, multiple regression indicated that aging affects 11 C-BU99008 volumes of distribution values in a region-specific manner. Independent samples t -test indicated that there was no significant group difference in 11 C-BU99008 volumes of distribution values between Parkinson's disease dementia ( n = 6; mean age = 71.97 ± 4.66 years) and older healthy controls ( n = 9; mean age = 71.90 ± 5.51 years). Our data set shows that astrogliosis is common with aging in a region-specific manner. However, in this set-up, 11 C-BU99008 PET cannot differentiate patients with Parkinson's disease dementia from healthy controls of similar age.
Keyphrases
- pet ct
- mild cognitive impairment
- computed tomography
- positron emission tomography
- cognitive impairment
- white matter
- magnetic resonance imaging
- clinical trial
- cerebral ischemia
- multiple sclerosis
- electronic health record
- subarachnoid hemorrhage
- blood brain barrier
- big data
- contrast enhanced
- data analysis
- double blind
- finite element