Sulfasalazine and Chromotrope 2B reduce oxidative stress in murine bone marrow-derived mesenchymal stem cells.

Hana'a Iqbal Nadia Naeem Kanwal Haneef Asmat Salim

Published in: Molecular biology reports (2023)

Our findings suggest that both Chromotrope 2B and Sulfasalazine possess the potential to reduce the ROS content in both age groups, though the latter was found to be more potent. These compounds can be used to precondition MSCs to enhance their regenerative potential for future cell-based therapeutics.

Keyphrases

mesenchymal stem cells
bone marrow
oxidative stress
cell therapy
stem cells
dna damage
umbilical cord
single cell
cell death
small molecule
ischemia reperfusion injury
induced apoptosis
climate change
signaling pathway
heat shock
heat stress
heat shock protein