Quantitation of neurofilament light chain protein in serum and cerebrospinal fluid from patients with multiple sclerosis using the MSD R-PLEX NfL assay.

Antigona UlndreajDorsa SohaeiSimon ThebaultOscar D Pons-BeldaAmaia Fernandez-UriarteChristopher CampbellDavid CheoMartin StengelinGeorge SigalMark S FreedmanIsobel A ScarisbrickIoannis PrassasEleftherios P Diamandis

Published in: Diagnosis (Berlin, Germany) (2023)

We show that MSD's R-PLEX NfL assay can reliably quantitate levels of NfL in the CSF and serum from patients with MS and controls, where levels correlate strongly with Simoa.

Keyphrases

cerebrospinal fluid
mass spectrometry
ms ms
high throughput
multiple sclerosis
liquid chromatography tandem mass spectrometry
high performance liquid chromatography
tandem mass spectrometry