Menstrual blood-derived mesenchymal stem cells attenuate inflammation and improve the mortality of acute liver failure combining with A2AR agonist in mice.
Da-Zhi ChenRuichao ZengGui-Gen TengChao CaiTongtong PanHanxiao TuHongwei LinQingjing DuHuahong WangYongping ChenPublished in: Journal of gastroenterology and hepatology (2021)
The MenSCs can attenuate the ALF-induced liver injury via inhibition of TLR4-mediated PI3K/Akt/mTOR/IKK signaling. Then, this inhibits the p-NF-κBp65 translocate into nuclear, which causes a decrease of inflammatory cytokines release. Moreover, A2AR agonist can play a synergic role with MenSCs and enhance the above-mentioned effects.
Keyphrases
- liver failure
- hepatitis b virus
- oxidative stress
- toll like receptor
- signaling pathway
- inflammatory response
- nuclear factor
- lps induced
- cardiovascular events
- immune response
- high fat diet induced
- pi k akt
- risk factors
- cell proliferation
- metabolic syndrome
- insulin resistance
- extracorporeal membrane oxygenation
- wild type