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Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription.

Ying FengYao WangXiangnan WangXiaohui HeChen YangArdalan NaseriThoru PedersonJing ZhengShaojie ZhangXiao XiaoWei XieSusan J Baserga
Published in: Genome biology (2020)
These results reveal the role of H3K9me3 in genome organization could be partially separated from its function in gene repression.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • gene expression
  • high resolution
  • transcription factor
  • single cell