SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens.

Hee-Dae KimJing WeiTanessa CallXiaokuang MaNicole Teru QuintusAlexander J SummersSamantha CarotenutoRoss JohnsonAngel NguyenYuehua CuiJin G ParkShenfeng QiuDeveroux Ferguson

Published in: Biological psychiatry (2024)

SIRT1 coordinates excitatory and inhibitory synaptic genes to regulate the GABAergic output tone of D1-MSNs. These findings reveal a novel signaling pathway that has potential for the development of innovative treatments for affective disorders.

Keyphrases

signaling pathway
genome wide
oxidative stress
ischemia reperfusion injury
depressive symptoms
pi k akt
bipolar disorder
epithelial mesenchymal transition
single cell
dna methylation
induced apoptosis
sleep quality
human health
gene expression
genome wide identification