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Mitochondrial dysfunction and ovarian aging.

Tianren WangMan ZhangZongliang JiangEmre Seli
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2017)
Mitochondria are double-membrane-bound organelles that are responsible for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular. Recent studies exploited this association by studying mitochondrial DNA (mtDNA) copy number as a potential biomarker of embryo viability and the use of mitochondrial nutrients and autologous mitochondrial transfer as a potential treatment for poor ovarian function and response.
Keyphrases
  • mitochondrial dna
  • copy number
  • genome wide
  • oxidative stress
  • cell therapy
  • dna methylation
  • cell death
  • dna damage
  • single cell
  • endothelial cells
  • bone marrow
  • heavy metals
  • climate change
  • reactive oxygen species