The role of adipose tissue and subsequent liver tissue hypoxia in obesity and early stage metabolic dysfunction associated steatotic liver disease.
Annelies van EyckWilhelmus J KwantenCédric PelemanSanae MakhoutSteven Van LaereKarolien Van De MaeleKim Van HoorenbeeckJoris De ManBenedicte Y De WinterSven FrancqueStijn L VerhulstPublished in: International journal of obesity (2005) (2023)
Diet-induced obesity in mice is associated with hypoxia in liver and adipose tissue. Adipose tissue hypoxia develops early in obesity, while liver hypoxia occurs later in the obesity development but still within the early stages of MASLD. Liver hypoxia could not be directly confirmed in a non-obese liver-only MASLD mice model, indicating that obesity-related processes such as adipose tissue hypoxia are important in the pathophysiology of obesity and MASLD.