Early-life exposure to the Chinese famine, genetic susceptibility and the risk of type 2 diabetes in adulthood.

Bin WangJing ChengHeng WanYuying WangWen ZhangYi ChenChi ChenFangzhen XiaMichael D JensenNingjian WangYing-Li Lu

Published in: Diabetologia (2021)

Prenatal exposure to famine was associated with an increased risk of type 2 diabetes in Chinese adults independent of genetic risk score using 21 variants common in the East Asian population. Famine exposure and genetic susceptibility may exhibit an additive effect on diabetes development.

Keyphrases

early life
copy number
genome wide
cardiovascular disease
pregnant women
glycemic control
adipose tissue
weight loss