A pilot study of preproinsulin peptides reactivity in Chinese patients with type 1 diabetes.

Yingxin XianHaixia XuYifang Gao Jianping WengJing LvWenqian RenQianwen HuangZiyu JiangFen XuBin YaoJian-Ping Weng

Published in: Diabetes/metabolism research and reviews (2019)

This is the first report of CD4+ T cell epitope mapping of PPI in Chinese T1D. The lack of positive IFN-γ response to PPI peptides indicates that PPI might not be the principal antigenic candidate for autoreactive CD4+ T cells in Chinese T1D. Therefore, the efficacy of PPI-based immunotherapies in attenuating proinflammatory CD4+ T cell response requires further investigation.

Keyphrases

protein protein
small molecule
high resolution
immune response
amino acid
dendritic cells
mass spectrometry
high density
monoclonal antibody