A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.

Khaoula Ben YounesSimon BodyÉlodie CostéPierre-Julien ViaillyHadjer MiloudiClémence CoudreFabrice JardinFatma Ben Aissa-FenniraBrigitte Sola

Published in: BMC cancer (2017)

The resistance of MCL cells to genotoxic stress correlates with a low 26S proteasome activity. This could represent a relevant biomarker for a subtype of MCL patients with a poor response to therapies and a high risk of relapse.

Keyphrases

induced apoptosis
cell cycle arrest
diffuse large b cell lymphoma
stress induced
cell death
signaling pathway
cell proliferation