Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study.
Rob MolenbergChris H L ThioMarlien W AalbersMaarten Uyttenboogaartnull nullSusanna C LarssonMark K BakkerYnte M RuigrokHarold SniederJ Marc C van DijkPublished in: Stroke (2022)
Genetic predisposition to elevated serum levels of SHBG, with secondary lower serum BioT levels, is associated with an increased aSAH risk among women, suggesting that SHBG and BioT causally elevate aSAH risk. Further studies are required to elucidate the underlying mechanisms and their potential as an interventional target to lower aSAH incidence.