Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels.

Kristin O'ConnorMark William DaviesPieter KoortsDavid W CartwrightKaren Whitfield

Published in: European journal of drug metabolism and pharmacokinetics (2021)

Gentamicin regimen of 2.5 mg/kg given every 36 h for neonates < 30 weeks GA and every 24 h for neonates ≥ 30 weeks GA was suboptimal at achieving therapeutic gentamicin peak. Increasing the dosage to 3.5 mg/kg achieved therapeutic peak concentrations in 98% and non-toxic trough concentrations in 86% of all neonates (prior to dose interval adjustment).

Keyphrases

low birth weight
pet ct
preterm infants
preterm birth
gestational age