Effect of Genetic Variability in 20 Pharmacogenes on Concentrations of Tamoxifen and Its Metabolites.

Yuanhuang Chen Lauren A MarcathFinn Magnus EliassenTone Hoel LendeHavard SoilandGunnar MellgrenThomas HellandDaniel Louis Hertz

Published in: Journal of personalized medicine (2021)

Multiple genes are involved in tamoxifen metabolism and multi-gene panels could be useful to predict active metabolite concentrations and guide tamoxifen dosing.

Keyphrases

genome wide
breast cancer cells
estrogen receptor
positive breast cancer
copy number
genome wide identification
dna methylation
ms ms
genome wide analysis
transcription factor