Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling.

Szu-Yuan WuWan-Yu YangChun-Chia ChengKuan-Hao LinBonifasius Putera SampurnaSuat-Ming ChanChiou-Hwa Yuh

Published in: Clinical and translational medicine (2017)

Taken together, we provide evidence that OF exhibits the anti-HCC, anti-steatosis, and anti-fibrosis effect for liver in zebrafish models, and the anti-cancer potential of OF attributed to the binding to ASGR and activation of STAT3/HNF4A signaling. OF might be potentially valuable for the management of HCC.

Keyphrases

cell proliferation
nuclear factor
insulin resistance
type diabetes
adipose tissue
climate change
toll like receptor
human health