Proinflammatory switch from Gαs to Gαi signaling by Glucagon-like peptide-1 receptor in murine splenic monocyte following burn injury.

Qing-Hong ZhangJi-Wei HaoGuang-Lei LiXiao-Jing JiXu-Dong YaoNing DongYong-Ming Yao

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2017)

This study presents an unexpected proinflammatory switch from Gαs to Gαi signaling in burn monocyte, which promotes ERK1/2 and NF-κB activation and the downstream TNF-α secretion. This phenomenon is most probably responsible for proinflammatory response evoked by Gαs agonist Exendin-4 following burn injury.

Keyphrases

signaling pathway
dendritic cells
wound healing
pi k akt
endothelial cells
rheumatoid arthritis
peripheral blood
cell proliferation
oxidative stress
nuclear factor
immune response
inflammatory response