Prognostic Value of Left Ventricular 18 F-Florbetapir Uptake in Systemic Light-Chain Amyloidosis.

Olivier F ClercYesh DatarSarah A M CuddyGiada BianchiAlexandra TaylorDominik C BenzMatthew RobertsonMarie Foley KijewskiMichael Jerosch-HeroldRaymond Y KwongFrederick L RubergRonglih LiaoMarcelo F Di CarliRodney H FalkSharmila Dorbala

Published in: JACC. Cardiovascular imaging (2024)

F-florbetapir uptake to subsequent outcomes, LV amyloid burden estimated by percent injected dose predicted MACE in AL amyloidosis. This effect was not independent of Mayo stage and was mediated primarily through NT-proBNP. These findings provide novel insights into the mechanism linking myocardial amyloid deposits to MACE.

Keyphrases

left ventricular
multiple myeloma
heart failure
hypertrophic cardiomyopathy
acute myocardial infarction
cardiac resynchronization therapy
aortic stenosis
mitral valve
left atrial
risk factors
metabolic syndrome
coronary artery disease
acute coronary syndrome
insulin resistance
aortic valve
weight loss