Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction-Induced Kidney Injury via Activation of the Intrarenal RAS.

Renfei LuoKevin T YangFei WangHuaqing ZhengTianxin Yang

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

Our results reveal that PRR-dependent/soluble PRR-dependent activation of CD renin represents a key determinant of the intrarenal RAS and, thus, obstruction-induced renal inflammation and fibrosis.

Keyphrases

high glucose
diabetic rats
oxidative stress
drug induced
wild type
angiotensin converting enzyme
endothelial cells
binding protein