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Highly accurate sequence imputation enables precise QTL mapping in Brown Swiss cattle.

Mirjam FrischknechtHubert PauschBeat BapstHeidi Signer-HaslerChristine FluryDorian GarrickChristian StrickerRuedi FriesBirgit Gredler-Grandl
Published in: BMC genomics (2017)
Our study demonstrates that whole-genome sequence information can be imputed at high accuracy in cattle populations. Using imputed sequence variant genotypes in genome-wide association studies may facilitate causal variant detection.
Keyphrases
  • genome wide association
  • high resolution
  • high density
  • amino acid
  • loop mediated isothermal amplification
  • mass spectrometry
  • label free
  • real time pcr
  • sensitive detection