Comparison of SIMOA and VEUS technologies for serum neurofilament light chain measurement in multiple sclerosis.
Ondrej PelisekPavlina KusnierovaPavel HradilekJana HorakovaKrystof SvubKaterina SiprovaOndrej SobekAravind GaneshPavla HanzlikovaOndrej VolnyKamila Zondra RevendovaPublished in: Multiple sclerosis and related disorders (2024)
Our investigation uncovered noteworthy disparities between the SIMOA and VEUS techniques in determining sNfL levels. Specifically, the VEUS technique systematically produces lower estimates of sNFL levels. This substantial variance emphasizes the importance of carefully evaluating assay methods when quantifying sNfL.