The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway.

Floriana Maria FarinaSimone SerioIgnacio Fernando HallStefania ZaniGiada Andrea Cassanmagnago Montserrat ClimentEfrem CiviliniGianluigi CondorelliManuela QuintavalleLeonardo Elia

Published in: European heart journal (2022)

DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results identify DOT1L as a potential therapeutic target for vascular diseases.

Keyphrases

gene expression
smooth muscle
dna methylation
cardiovascular disease
energy transfer
signaling pathway
single cell
dendritic cells
oxidative stress
cell therapy
endothelial cells
pi k akt
peripheral blood
risk assessment
inflammatory response