The development of novel sonosensitizers with outstanding reactive oxygen (ROS) generation capacity and great biocompatibility poses a significant challenge for the clinical practice of sonodynamic therapy (SDT). In this work, hemoglobin (Hb) with natural metalloporphyrin was first shown to possess great potential as a sonosensitizer. Compared with traditional organic sonosensitizers, Hb had satisfactory sono-sensitizing efficiency because four the porphyrin molecules were separated by four polypeptide chains. This effectively avoided the problem of low ROS quantum yield caused by the stacking of hydrophobic porphyrins. Meanwhile, Hb is an efficient and safe oxygen carrier that may release O2 at hypoxic tumors site, which improved tumor oxygenation and subsequently enhanced SDT efficacy. Therefore, Hb was integrated with zeolitic imidazolate framework 8 (ZIF-8) to form a nanoplatform that demonstrated a potent suppression effect on deep-seated tumors under ultrasound irradiation.
Keyphrases
- cancer therapy
- clinical practice
- photodynamic therapy
- cell death
- dna damage
- drug delivery
- reactive oxygen species
- magnetic resonance imaging
- energy transfer
- molecular dynamics
- red blood cell
- ionic liquid
- ultrasound guided
- radiation therapy
- anti inflammatory
- radiation induced
- contrast enhanced ultrasound
- tissue engineering
- quantum dots
- drug release
- aqueous solution
- monte carlo