Preclinical evaluation of the novel [ 18 F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease.
Franziska ZajicekJeroen VerhaegheStef De LombaerdeAnnemie Van EetveldtAlan MirandaIgnacio Munoz-SanjuanCelia DominguezVinod KhetarpalJonathan A BardLongbin LiuSteven StaelensDaniele BertoglioPublished in: European journal of nuclear medicine and molecular imaging (2024)
F radioligand to image mHTT aggregates in mice and its clinical evaluation is underway.