Development and validation of a clinical decision support system based on PSA, microRNAs, and MRI for the detection of prostate cancer.

Simone MazzettiArianna DefeudisGiulia NicolettiGiovanna ChiorinoStefano De LucaRiccardo FalettiMarco GattiPaolo GonteroMatteo ManfrediMaurizia Mello-GrandCaterina Peraldo-NeiaAndrea ZitellaFrancesco PorpigliaDaniele ReggeValentina Giannini

Published in: European radiology (2024)

• Clinical decision support systems including MRI improve the detection of both prostate cancer and clinically significant prostate cancer with respect to PSA test and/or microRNA. • The use of miRNAs let-7a-5p and miR-103a-3p did not significantly improve MRI stand-alone performance. • Results of this study were in line with previous works on MRI and microRNA.

Keyphrases

prostate cancer
clinical decision support
radical prostatectomy
contrast enhanced
magnetic resonance imaging
electronic health record
diffusion weighted imaging
computed tomography
loop mediated isothermal amplification
real time pcr
quantum dots