Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells.
Emanuela CavatortaJens VoskuhlDorothee WasserbergJenny BrinkmannJurriaan HuskensPascal JonkheijmPublished in: RSC advances (2017)
Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targeting ligands. These vesicles were employed for loading and delivery of proteins into cells. Supramolecular amphiphile-derived vesicles show great promise as nanocarriers of functional molecules to be transferred into cells.
Keyphrases
- induced apoptosis
- cell cycle arrest
- drug delivery
- endoplasmic reticulum stress
- cell death
- quantum dots
- oxidative stress
- signaling pathway
- photodynamic therapy
- cell proliferation
- high resolution
- drug release
- cell therapy
- reduced graphene oxide
- optical coherence tomography
- optic nerve
- molecularly imprinted
- pulmonary fibrosis