Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.

Carmela De SantoPaul ChengAndrew BeggsSharon EganAlberto BessudoFrancis Jay Mussai

Published in: Journal of hematology & oncology (2018)

Targeting arginine metabolism with therapeutic arginase in arginine auxotrophic melanoma can be an effective salvage for the treatment of patients who fail immunotherapy.

Keyphrases

nitric oxide
nitric oxide synthase
drug delivery
skin cancer
cancer therapy
stem cells
basal cell carcinoma
systemic lupus erythematosus
ulcerative colitis
replacement therapy
bone marrow