A hybrid computational strategy to address WGS variant analysis in >5000 samples.

Zhuoyi HuangNavin RustagiNarayanan VeeraraghavanAndrew CarrollRichard GibbsEric BoerwinkleManjunath Gorentla VenkataFuli Yu

Published in: BMC bioinformatics (2016)

Even with increasing sizes of whole genome datasets, ensemble joint calling of SNVs for low coverage data can be accomplished in a scalable, cost effective and fast manner by using heterogeneous computing platforms without compromising on the quality of variants.

Keyphrases

electronic health record
copy number
big data
healthcare
rna seq
quality improvement
dna methylation
data analysis
neural network
deep learning