Sigma-1 receptor activation-induced glycolytic ATP production and endothelial barrier enhancement.
Zeinab Y MotaweForouzandeh FarsaeiSalma S AbdelmaboudJavier CuevasJerome W BreslinPublished in: Microcirculation (New York, N.Y. : 1994) (2020)
Activation of σ1 enhances endothelial barrier function and modulates the ratio of glycolytic versus mitochondrial ATP production. These novel findings suggest that endothelial σ1 may prove beneficial as a novel therapeutic target for reducing microvascular hyperpermeability and counteracting mitochondrial dysfunction.